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Increased endothelin concentration in CSF from patients with subarachnoid hemorrhage
Author(s) -
Suzuki H.,
Sato S.,
Suzuki Y.,
Takekoshi K.,
Ishihara N.,
Shimoda S.
Publication year - 1990
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1990.tb01018.x
Subject(s) - subarachnoid hemorrhage , vasospasm , medicine , endothelin receptor , endothelin 1 , anesthesia , endothelin 3 , endothelins , receptor
A considerable quantity of endothelin‐like immunoreactivity was demonstrated as present in the CSF of patients with subarachnoid hemorrhage. The endothelin levels in the CSF raised from 0.4 ± 0.2 (Mean ± SD) pmol/L at Day 0‐1 to 2.2 ± 0.6 pmol/L at Day 6 and the levels decreased gradually. The result suggest that endothelin may contribute the generation of vasospasm often observed in subarachnoid hemorrhage.