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Blood‐brain‐barrier and intrathecal immunoglobulin changes in tuberculous meningitis and demyelinating disorders: a preliminary report from a South Indian hospital
Author(s) -
Prabhakar S.,
Basha A.,
Bhagyalakshmi G.,
Oommen A.
Publication year - 1990
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1990.tb00993.x
Subject(s) - albumin , medicine , tuberculous meningitis , serum albumin , intrathecal , meningitis , gastroenterology , immunology , csf albumin , cerebrospinal fluid , anesthesia , surgery
Sixty‐three paired serum and CSF samples (15 controls and 48 patients) were studied for CSF albumin quotient, IgG index and synthesis rate. Control values for albumin quotient and IgG index were < 10.0 and < 0.6 respectively. IgG synthesis rate/day was calculated according to the Tourtellotte formula and a value of > 3.0 mg/day is considered high. Our findings in patients with central demyelinations, subacute sclerosing pan‐encephalitis, Guillain Barre Syndrome and cerebrovascular accidents are comparable to earlier studies. Fifteen tuberculous meningitis patients were studied and could be separated into 2 groups, 9 with elevated albumin quotients and 6 with normal albumin quotients. Three patients with elevated albumin quotients and 4 with normal albumin quotients showed increased intrathecal IgG synthesis.