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Clinical and computer‐based assessment of long‐term therapeutic efficacy of propranolol in essential tremor
Author(s) -
Calzetti S.,
Sasso E.,
Baratti M.,
Fava R.
Publication year - 1990
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1990.tb00982.x
Subject(s) - propranolol , essential tremor , medicine , drug , clinical efficacy , therapeutic effect , anesthesia , intensive care medicine , surgery , physical medicine and rehabilitation , pharmacology
Despite a large number of studies demonstrating the effectiveness of propranolol in relieving essential tremor (ET) the long‐term therapeutic outcome of these patients remains poorly defined. The results of a one‐year follow‐up study in 18 patients with mild to severe ET performed by using clinical and computer‐based methods of assessment indicate that the initial therapeutic benefit of propranolol is apparently retained. However, following 3–6 months of sustained treatment a proportion of patients required an increase in daily dosage of propranolol in order to maintain adequate symptomatic control of tremor, indicating a relative decrease in tremorolytic efficacy of the drug possibly due to long‐term tolerance.