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Glucose phosphorylation rate in rat parietal cortex during normoglycemia, hypoglycemia, acute hyperglycemia, and in diabetes‐prone rats
Author(s) -
Brøndsted H. E.,
Gjedde A.
Publication year - 1990
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1990.tb00972.x
Subject(s) - medicine , endocrinology , hypoglycemia , diabetes mellitus , insulin , posterior parietal cortex , carbohydrate metabolism , plasma glucose , intraperitoneal injection , cortex (anatomy) , cerebral cortex , chemistry , biology , neuroscience
Cerebral metabolic rate for glucose (CMRglc) was studied in rats using [6‐ ‐14 C]glucose. After intravenous injection, the radioactivity of the parietal cortex was corrected for loss of labeled CO2 and divided by the integral of the arterial plasma glucose concentration, determined during tracer circulation. Treatment with insulin, resulting in plasma glucose concentrations less than 2.6 mmol/l, reduced CMRglc to 64% of the values found in control animals. CMRglc did not change in animals with acute hyperglycemia produced by intraperitoneal injection of a glucose solution or in diabetes‐prone rats with or without insulin treatment.