Premium
Mast cells and multiple sclerosis: a light and electron microscopic study of mast cells in multiple sclerosis emphasizing staining procedures
Author(s) -
Krüger P. G.,
Bø L.,
Myhr K. M.,
Karlsen Å. E.,
Taule A.,
Nyland H. I.,
Mørk S.
Publication year - 1990
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1990.tb00927.x
Subject(s) - multiple sclerosis , staining , pathology , medicine , myelin sheath , white matter , mast cell , central nervous system , immunology , myelin , magnetic resonance imaging , radiology
In the brains of 7 patients with multiple sclerosis, mast cells were observed within the demyelinated plaques, in the border zone of the plaques as well as in seemingly normal white matter. The cells were mostly located in close connection with small vessels. The routine staining with toluidine blue for the demonstration of mast cells is not adequate as compared with staining of similar sections in pinacyanol erythrosine. Mast cells may be a hitherto underestimated contributor to the demyelinating process of multiple sclerosis.