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Intrathecal synthesis of beta‐2‐microglobulin in multiple sclerosis and aseptic meningo‐encephalitis
Author(s) -
Us Ö.,
Lolli F.,
Baig S.,
Link H.
Publication year - 1989
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1989.tb03934.x
Subject(s) - multiple sclerosis , beta 2 microglobulin , cerebrospinal fluid , aseptic meningitis , beta (programming language) , medicine , intrathecal , encephalitis , gastroenterology , central nervous system , pathology , immunology , anesthesia , virus , computer science , programming language
Beta‐2‐microglobulin (β 2 m) levels were studied in the cerebrospinal fluid (CSF) and plasma of 52 patients with clinically definite multiple sclerosis (MS) and of 14 with aseptic meningo‐encephalitis (AM). Reference values for β 2 m were defined in 72 subjects of different age groups with tension headache (TH). Plasma levels of β 2 m increased with age in TH controls, particularly in the older age group, while no significant age variation could be detected for CSF β 2 m. Increased levels of β 2 m were found in the CSF and plasma of AM patients and in the CSF in MS. Calculations of CSF/plasma β 2 m ratios showed higher values in AM, reflecting intrathecal β 2 m synthesis, while only borderline alterations were evident in MS. Demonstration of intrathecal production of β 2 m is an additional CSF finding that may be useful in evaluating, among others, inflammatory nervous system disorders, but it has limited importance in the study of MS patients.