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Retrovirus in multiple sclerosis
Author(s) -
KamHansen S.,
Lu C. Z.,
Fredrikson S.,
Baig S.
Publication year - 1989
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1989.tb03911.x
Subject(s) - retrovirus , multiple sclerosis , peripheral blood mononuclear cell , reverse transcriptase , cytopathic effect , endogenous retrovirus , medicine , virology , immunology , biology , virus , in vitro , gene , polymerase chain reaction , genetics , genome
— Presence of cytopathic effect and enzyme reverse transcriptase in cultures of peripheral blood mononuclear cells is described in 2 of 15 patients with multiple sclerosis and none of healthy controls. These findings might indicate: the presence of a new human retrovirus in these individuals, despite the low detection rate, and the shortcomings inherent in methodology used for detection of known human retroviruses in the study of new groups of diseases, such as those with possible autoimmune background.