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CSF choline and acetylcholinesterase in early‐onset vs. late‐onset Alzheimer's disease patients
Author(s) -
Kumar V.,
Giacobini E.,
Markwell S.
Publication year - 1989
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1989.tb03910.x
Subject(s) - acetylcholinesterase , aché , medicine , cerebrospinal fluid , endocrinology , dementia , alzheimer's disease , age of onset , choline , disease , gastroenterology , biology , enzyme , biochemistry
— Cerebrospinal fluid acetylcholinesterase (AChE) activity levels and choline (Ch) levels were studied in 52 dementia of Alzheimer type (DAT) patients and 20 age‐matched controls. The AChE activity was significantly lower and Ch levels were significantly higher in DAT patients than the age‐matched controls. There was no significant difference in AChE activity and Ch levels between early‐onset (>65 years) patients and late‐onset (<65 years) patients. However, the AChE activity was significantly lower in early‐onset patients compared with age‐matched controls but no difference was observed in late‐onset patients compared with their age‐matched controls. None of the biological measures (AChE, Ch) were significantly correlated with the degree of cognitive impairment, duration of the illness or the sex of these patients.