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Prevention of ischemic neuronal damage by α 1‐adrenoceptor agonist (methoxamine)
Author(s) -
Araki T.,
Kogure K.,
Izumiyama K.
Publication year - 1989
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1989.tb03908.x
Subject(s) - methoxamine , gerbil , agonist , ischemia , medicine , stimulation , hippocampus , anesthesia , saline , calcium , endocrinology , cardiology , receptor
— The effect of methoxamine, an α 1‐adrenoceptor agonist, on ischemic neuronal damage was studied in the gerbil. The animals were subjected to 5 min of ischemia by bilateral common carotid arteries occlusion. Morphological changes and calcium accumulation were evaluated in the CA1 sector of the hippocampus after 7 days of survival. The degree of ischemic neuronal damage and calcium accumulation in the methoxamine‐treated groups were significantly attenuated compared with the saline‐treated ischemic group. The results suggest that α 1‐adrenoceptor stimulation prevents ischemic neuronal damage.