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Interleukin 1 and 2 production by peripheral blood mononuclear cells in subacute sclerosing panencephalitis and exacerbation of multiple sclerosis
Author(s) -
BrajczewskaFischer W.,
Iwińska B.,
Kruszewska J.,
Korlak J.,
Czlonkowska A.
Publication year - 1989
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1989.tb03899.x
Subject(s) - subacute sclerosing panencephalitis , peripheral blood mononuclear cell , exacerbation , pathogenesis , multiple sclerosis , medicine , immunology , interleukin , peripheral blood , peripheral , in vitro , pathology , cytokine , chemistry , measles , measles virus , biochemistry , vaccination
— Il‐1 and Il‐2 production by peripheral blood mononuclear cells was studied in 10 patients with SSPE and 15 patients in the acute stage of MS. Both SSPE and MS cells in vitro released spontaneously high amounts of Il‐1, and could not be further stimulated to synthesis of Il‐1 by latex. The Il‐2 production was decreased in both processes but in MS after the recovery from the acute stage the production of Il‐2 increased. The role of the observed changes in both Il‐1 and Il‐2 secretion in the pathogenesis of SSPE and MS is unknown.