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Blood lipid peroxides in TIA: relation to platelet function and metabolic profile
Author(s) -
Violi F.,
Alessandri C.,
Ghiselli A.,
Germani M.,
Caliendo C.,
Censi C.,
Servi M.,
Balsano F.
Publication year - 1989
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1989.tb03877.x
Subject(s) - medicine , hypertriglyceridemia , platelet , aspirin , endocrinology , diabetes mellitus , thiobarbituric acid , arachidonic acid , chemistry , gastroenterology , cholesterol , triglyceride , biochemistry , oxidative stress , lipid peroxidation , enzyme
— Patients with transient ischemic attacks (TIA) were previously shown to have high plasma values of thiobarbituric acid‐reactive substances (TBA‐RS). To study whether these changes could be related to platelet activability. TBA‐RS was investigated in 24 TIA patients before and 24 h after 1 g aspirin, an inhibitor of platelet cyclooxygenase pathway. Baseline TBA‐RS values were significantly higher in TIA than in controls. Conversely, TIA patients had TBA‐RS values after aspirin similar to controls, suggesting that the increase of plasma TBA‐RS was not attributable to platelet hyperfunction. The evaluation of metabolic profile showed that patients with highest TBA‐RS had hypercholesterolemia, hypertriglyceridemia, and/or diabetes mellitus. This study suggests that the increase of plasma TBA‐RS in TIA could be an epiphenomenon of altered metabolic pathway.