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Characterization of acetylcholine receptor antibodies in a patient with primary biliary cirrhosis
Author(s) -
Lefvert A. K.,
Holm G.
Publication year - 1989
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1989.tb03871.x
Subject(s) - myasthenia gravis , primary biliary cirrhosis , acetylcholine receptor , antibody , isotype , medicine , biliary cirrhosis , immunology , receptor , neuromuscular junction , in vivo , biology , monoclonal antibody , autoimmune disease , neuroscience , microbiology and biotechnology
— Antibodies against the acetylcholine receptor were found in a patient with primary biliary cirrhosis. The patient had no clinical or electrophysiological evidence of disturbed neuromuscular function. The antibodies were of both IgG and IgM isotype. Following passive transfer, these antibodies showed the same capacity to bind in vivo to mouse muscle receptors as immunoglobulins from patients with myasthenia gravis. The affinity of the antibodies was high and comparable to that found in myasthenia gravis patients.