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Metabolism of vitamin D 2 and vitamin D 3 in patients on anticonvulsant therapy
Author(s) -
Hartwell D.,
Tjellesen L.,
Christiansen C.,
Rødbro P.
Publication year - 1989
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1989.tb03819.x
Subject(s) - vitamin d and neurology , medicine , endocrinology , vitamin , anticonvulsant , chemistry , vitamin d deficiency , metabolism , cholecalciferol , serum concentration , epilepsy , psychiatry
— We examined the effect of short‐term treatment with pharmacological doses of vitamin D 2 or vitamin D 3 on the serum concentration of 1,25(OH) 2 D metabolites in epileptic patients on chronic anticonvulsant drug therapy. Nine patients were studied before and after treatment with vitamin D 2 4000 IU daily for 24 weeks and 10 before and after treatment with vitamin D 3 in the same dose. Before treatment the serum concentrations of 1,25(OH) 2 D and 25(OH)D were significantly lower in epileptics than in normal subjects ( P <0.01). Vitamin D 2 treatment increased the serum concentration of 1,25(OH) 2 D 2 , but a corresponding decrease in 1,25(OH) 2 D 3 resulted in an unchanged serum concentration of total 1,25(OH) 2 D. The serum concentration of 25(OH)D 2 and 25(OH)D increased significantly, whereas there was a small decrease in 25(OH)D 3 . Vitamin D 3 treatment did not change the serum concentration of 1,25(OH) 2 D 3 whereas serum 25(OH)D 3 increased significantly. The correlation between the serum ratio of 1,25(OH) 2 D 2 /1,25(OH) 2 D 3 and 25(OH)D 2 /25(OH)D 3 estimated on vitamin D 2 ‐treated epileptic patients and normal subjects was highly significant ( P <0.01). The data indicate that the serum concentration of 1,25(OH) 2 D 2 and 1,25(OH) 2 D 3 are directly proportional to the amount of their precursors 25(OH)D 2 and 25(OH)D 3 and that the concentration of total 1,25(OH) 2 D is tightly regulated.