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Peripheral nerve function during hyperglycemic clamping in insulin‐dependent diabetic patients
Author(s) -
Sindrup S. H.,
Ejlertsen B.,
Gjessing H.,
Svendsen A.,
Froland A.
Publication year - 1989
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1989.tb03809.x
Subject(s) - medicine , endocrinology , nerve conduction velocity , insulin , sensory nerve , motor nerve , peripheral , sensory system , basal (medicine) , diabetes mellitus , anatomy , psychology , cognitive psychology
— The influence of hyperglycemia on peripheral nerve function was studied in 9 patients with long‐term insulin‐dependent diabetes. Blood glucose concentration was raised 13.5±0.5 mmol/1 (mean±SEM) within 15 min and kept approximately 15 mmol/1 over basal level for 120 min by intravenous glucose infusion. Hyperglycemia was accompanied by increased plasma osmolality. Sensory and motor nerve conduction and distal motor latency in the ulnar nerve were determined before, immediately after induction of hyperglycemia, and again after 120 min hyperglycemia. Distal (5th finger‐wrist) and proximal (wrist‐elbow) sensory nerve conduction showed an insignificant increase as hyperglycemia was induced. During hyperglycemia mean distal sensory conduction decreased from 53.1 m/s to 50.4 m/s (P < 0.05) and mean proximal sensory conduction decreased from 56.0 m/s to 54.2 m/s (P < 0.01). A mean of distal and proximal sensory conduction increased (53.5 m/s vs 54.6 m/s) (P < 0.05) as hyperglycemia was induced and decreased (54.6 m/s vs 52.3 m/s) (P < 0.01) during clamping. Motor nerve conduction decreased insignificantly throughout the study. Mean distal motor latency decreased from 3.1 ms to 2.8 ms (P< 0.005) immediately after induction of hyperglycemia. During hyperglycemia it increased from 2.8 ms to 3.1 ms (P< 0.001). We conclude that acute induction of hyperglycemia in long‐term diabetics seems to increase sensory conduction and decrease distal motor latency, while 120 min hyperglycemia seems to decrease sensory conduction and increase distal motor latency. As the changes are small, it may not be necessary to pay attention to the concomitant blood glucose concentration when sequential nerve conduction measurements are made in diabetics.