Premium
Zinc, copper and magnesium concentration in serum and CSF of patients with neurological disorders
Author(s) -
Kapaki E.,
Segditsa J.,
Papageorgiou C.
Publication year - 1989
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1989.tb03803.x
Subject(s) - cerebrospinal fluid , zinc , magnesium , multiple sclerosis , medicine , serum concentration , subarachnoid space , copper , endocrinology , chemistry , gastroenterology , immunology , organic chemistry
— Zinc (Zn), copper (Cu) and magnesium (Mg) concentrations in cerebrospinal fluid (CSF) and serum were determined with atomic absorption spectrophotometry in 74 patients suffering from various neurological diseases, and in 28 healthy controls. Increased CSF zinc levels were found in the group of peripheial nervous system diseases ( P <0.01) and in the cases of different neurological syndromes with increased CSF protein concentration ( P <0.001). Increased CSF and serum copper levels were found in the cases with increased CSF protein levels ( P <0.05). It is probable that the damaged blood‐brain‐barrier (BBB) permits the passage of the trace elements Zn, Cu and of Mg into the subarachnoid space. Decreased serum Cu levels ( P < 0.01) were found in the group of multiple sclerosis (MS). The findings are correlated to those of previous communications.