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Neuropeptides and neural cell adhesion molecule (NCAM) in CSF from patients with ALS
Author(s) -
Werdelin L.,
Gjerris A.,
Boysen G.,
Fahrenkrug J.,
Jørgensen O.S.,
Rehfeld J.F.
Publication year - 1989
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1989.tb03735.x
Subject(s) - neural cell adhesion molecule , vasoactive intestinal peptide , neuropeptide , cholecystokinin , amyotrophic lateral sclerosis , cell adhesion molecule , endocrinology , medicine , chemistry , neural cell , cell adhesion , cell , immunology , biochemistry , receptor , disease
— In 10 patients with amyotrophic lateral sclerosis (ALS), the CSF content of the neuropeptides vasoactive intestinal polypeptide (VIP) and cholecystokinin (CCK) as well as neural cell adhesion molecule (NCAM) was investigated. Compared with normal controls, no deviations were found in CCK or NCAM, while the values of VIP were significantly lower in ALS patients. This finding may reflect a loss of motor neurons.