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CSF choline levels in neurologically disturbed children
Author(s) -
Flentge F.,
Begeer J.H.,
Meulen W.R.E.H. MulderHajonides,
Teelken A.W.
Publication year - 1989
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1989.tb03730.x
Subject(s) - choline , cerebrospinal fluid , psychomotor learning , medicine , lumbar , endocrinology , surgery , cognition , psychiatry
— Choline levels in cerebrospinal fluid (CSF) were measured in a large group of neurologically disturbed children ( n = 114) and in a control group ( n = 15). Only 5 children showed CSF choline levels that differed more than 2 standard deviations from the mean of the total investigated group, suggesting that CSF choline levels are extremely stable. Of the 5 children showing extreme values, 3 suffered primarily from psychomotor retardation. Further analysis showed that the CSF choline levels in the medication‐free patient group suffering from psychomotor retardation ( n = 18) were significantly elevated in comparison with the control group. CSF choline levels of children were found to fit excellently in the regression line showing the increase of CSF choline levels with age as calculated earlier for adults. Therefore, CSF choline levels appear to increase linearly with age during the whole life span. From direct measurements and from measurements in consecutive fractions of lumbar CSF it is concluded that choline levels in intracranial CSF are 2–3 fold as high as those in lumbar CSF.