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CSF and serum β‐2‐microglobulin in HIV infection related to neurological dysfunction
Author(s) -
Elovaara I.,
Livanainen M.,
Poutiainen E.,
Valle S.L.,
Weber T.,
Suni J.,
Lähdevirta J.
Publication year - 1989
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1989.tb03717.x
Subject(s) - asymptomatic , beta 2 microglobulin , aids related complex , medicine , gastroenterology , human immunodeficiency virus (hiv) , beta (programming language) , cerebrospinal fluid , immunopathology , immunology , viral disease , computer science , programming language
— Elevated (< 2.2 mg/l) CSF β‐2‐microglobulin (β 2 m) level was found in 9 of 16 neurologically symptomatic patients but in only 4 of 21 who were neurologically symptom‐free ( P < 0.01). Serum β 2 m concentration was elevated (<2.5 mg/l) in 12 of 16 neurologically symptomatic patients but in only 8 of 21 symptom‐free patients ( P < 0.01). When the CSF and serum β 2 m levels were related to various stages of HIV infection, the highest mean values for both CSF and serum were found in patients with acquired immunodeficiency syndrome (AIDS), followed by lower values in AIDS‐related complex (ARC), lymphadenopathy syndrome (LAS), and asymptomatic seropositive individuals (ASX), in decreasing order of preference. Our results suggest that elevated β 2 m in CSF and serum is related to the stage of general HIV infection and that elevated CSF β 2 m in the presence of intact BBB may be useful in evaluating CNS involvement in HIV‐infected patients.