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Reversible brain cell damage due to hypoglycemia in a patient with insulinoma
Author(s) -
Ronquist G.,
Frithz G.
Publication year - 1989
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1989.tb03713.x
Subject(s) - insulinoma , unconsciousness , hypoglycemia , medicine , cerebrospinal fluid , brain damage , endocrinology , glycolysis , adenylate kinase , anesthesia , insulin , metabolism , receptor
— A case of an insulinoma with hypoglycemic attacks accompanied by episodes of unconciousness in a 57‐year‐old woman is described. During the hypoglycemic spells the level of adenylate kinase (AK) in the cerebrospinal fluid (CSF) was elevated 6‐fold above the normalized level obtained later from the patient being in a normoglycemic condition. CSF‐AK was previously found to be a sensitive marker of subtle brain cell damage due to hypoxia. The increased efflux of AK into CSF during the insulinoma‐induced hypoglycemia was most probably the result of a brain cell injury caused by shortage of glycolytic fuel.