Premium
Red blood cell fatty acids in multiple sclerosis
Author(s) -
Navarro X.,
Segura R.
Publication year - 1989
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1989.tb03706.x
Subject(s) - arachidonic acid , phospholipid , multiple sclerosis , linoleic acid , chemistry , red cell , red blood cell , medicine , endocrinology , composition (language) , fatty acid , biochemistry , immunology , membrane , enzyme , linguistics , philosophy
— The fatty acid (FA) composition of each phospholipid constituent of the red blood cells (RBC) was analyzed, by thin‐layer and gas chromatography techniques, in 61 multiple sclerosis (MS) patients and 61 normal subjects, in whom the plasma lipid FA composition had previously been studied. The MS patients showed a significant decrease in the proportions of linoleic and arachidonic acids in most phospholipids, with a compensatory increase of saturated FA. Correlations between FA percentages in plasma and cell lipids demonstrated abnormalities in the MS patients, suggestive of a disturbance in the exchange between these compartments. The alterations reported in plasma and RBC in the MS patients are consistent with a relative deficiency of essential FA