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Skeletal muscle contraction characteristics in vivo in malignant hyperthermia susceptible subjects
Author(s) -
Bäckman E.,
Lennmarken C.,
Rutberg H.,
Henriksson K. G.
Publication year - 1988
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1988.tb05910.x
Subject(s) - malignant hyperthermia , contraction (grammar) , skeletal muscle , medicine , muscle contraction , hyperthermia , in vivo , anesthesia , biology , microbiology and biotechnology
— Ten malignant hyperthermia susceptible (MHS) subjects were investigated, all of them positive in in vitro tests. As a control group 12 healthy subjects were investigated. The investigation was done in a blind fashion during strictly standardized conditions. Electromechanical delay of contraction and half contraction time to tetanus were faster ( P < 0.05) while half relaxation time was shorter in the MHS subjects ( P < 0.05). Skin and intramuscular temperature were significantly higher in the MHS subjects ( P < 0.05). This indicates that MHS subjects differ in various skeletal muscle characteristics during “normal” conditions. Further studies to define the temperature level at which the test of muscle function is most discriminating are needed before it can be used for diagnostic purposes.