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Diagnostic value of elastase‐α 1 ‐proteinase inhibitor in cerebrospinal fluid
Author(s) -
Speer Ch. P.,
Rocchetti C.,
Rethwilm M.,
Hohenwallner W.
Publication year - 1988
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1988.tb03696.x
Subject(s) - aseptic meningitis , cerebrospinal fluid , meningitis , elastase , bacterial meningitis , alpha (finance) , gastroenterology , medicine , microbiology and biotechnology , microgram , pancreatic elastase , pathology , immunology , biology , enzyme , surgery , biochemistry , in vitro , construct validity , patient satisfaction
‐ In this report we introduce CSF Elastase‐α 1 ‐Proteinaseinhibitor as a valuable indicator for differentiating bacterial meningitis from aseptic meningitis and other neurological disorders. All patients (n = 26) with bacterial meningitis had increased CSF concentrations of E‐α 1 ‐PI above the range of normal (range of reference values: 0.0–2.3 μg/1, n = 79; bacterial meningitis: 30–3490 μg/1, n = 26). Concentrations of E‐α 1 ‐PI in bacterial meningitis were significantly elevated when compared with those in aseptic meningitis (0.0–194 μg/1, n = 37), polyneuropathy (0–23 μg/1, n = 24) and cerebrovascular attack (0–23.2 μg/1, n = 17).