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Reduced prealbumin (transthyretin) in CSF of severely demented patients with Alzheimer's disease
Author(s) -
Riisøen H.
Publication year - 1988
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1988.tb03687.x
Subject(s) - transthyretin , dementia , cerebrospinal fluid , choroid plexus , medicine , disease , alzheimer's disease , gastroenterology , pathology , central nervous system
‐ Prealbumin (transthyretin) quantified in CSF was negatively correlated with degree of dementia in 24 patients with dementia of Alzheimer type (DAT). There was neither a significant correlation between prealbumin in serum and degree of dementia nor between prealbumin in CSF and number of T lymphocytes in serum. There was no such relationship in 7 patients with multiinfarct dementia. Prealbumin was also quantified in 4 non‐demented control groups, one consisting of 14 age‐ and sex‐matched neurological patients, 17 with MS, 6 with ALS and 10 patients who had had a subarachnoid hemorrhage. Prealbumin was significantly lower in the last group. The study suggests that there may be a relationship between prealbumin levels in cerebrospinal fluid and degree of dementia. It is suggested that this may be caused by affection of the choroid plexus.