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Selenium and vitamin E treatment of Duchenne muscular dystrophy: no effect on muscle function
Author(s) -
Bäckman E.,
Nylander E.,
Johansson I.,
Henriksson K. G.,
Tagesson C.
Publication year - 1988
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1988.tb03681.x
Subject(s) - duchenne muscular dystrophy , muscular dystrophy , medicine , vitamin e , selenium , physical medicine and rehabilitation , chemistry , biochemistry , antioxidant , organic chemistry
‐ 16 boys with Duchenne muscular dystrophy (DMD) were treated with sodium selenite and vitamin E for one year. One group of patients (10 boys) was examined using a battery of tests to assess muscular strength and function and cardiopulmonary function, and by CT scanning of 2 muscle groups over the 4 years prior to treatment. Six boys with DMD entered the study when the treatment was begin. Tests of muscular force and function, cardiopulmonary tests and CT‐scanning were performed at the onset of treatment, and after 6 and 12 months. No beneficial effect on either muscular force or function was found during the treatment period. It is concluded that selenium and vitamin E in high doses do not improve muscle function in DMD.