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Class and IgG subclass distribution of antibodies against peripheral nerve myelin in sera from patients with inflammatory demyelinating polyradiculoneuropathy
Author(s) -
Vedeler C. A.,
Matre R.,
Nyland H.
Publication year - 1988
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1988.tb03676.x
Subject(s) - polyradiculoneuropathy , subclass , myelin , immunology , medicine , antibody , guillain barre syndrome , central nervous system
‐ An enzyme‐linked immunosorbent assay (ELISA) was used to quantify antibodies against peripheral nerve myelin (PNM) in sera from 90 patients with Guillain‐Barré syndrome (GBS) and from 70 patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). Fifty‐nine percent of the patients with GBS and 51% of the patients with CIDP had increased levels of anti‐PNM antibodies. Antibodies were also found in 0%–14% of sera from patients with other neurological diseases and in 8% of normal blood donors. Mean levels of IgG, IgM and IgA anti‐PNM antibodies were increased in sera from patients with GBS, and mean IgG and IgA anti‐PNM antibody levels were increased in sera from patients with CIDP when compared with sera from normal blood donors. The mean IgG anti‐PNM antibody response observed in patients with GBS or CIDP was dominated by the IgG1 and IgG3 subclasses.