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Effect of dihydroergotoxine mesylate (Hydergine®) on delayed neuronal death in the gerbil hippocampus
Author(s) -
Izumiyama K.,
Kogure K.
Publication year - 1988
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1988.tb03649.x
Subject(s) - gerbil , hippocampus , ischemia , medicine , endocrinology , anesthesia
‐ The CA 1 neurons in the gerbil hippocampus exhibiting necrosis with delayed onset following 5 min ischemia were reduced markedly by the systemic administration of dihydroergotoxine mesylate (Hydergine®; HYG). Immediately after 5 min of forebrain ischemia, the animals were injected intraperitoneally with HYG. Seven days after ischemia, perfusion‐fixed brains were processed by conventional histology. The number of neurons per millimeter in the CA 1 pyramidal cell layer were calculated and they were labelled neuronal density. In the control group, the neuronal density was 66.03. ± 7.37 (mean ± SEM), in the vehicle group, it was 11.25 ± 4.93. The neuronal density in the HYG group was 69.19 ± 6.49. The difference in the neuronal density between the HYG group and the control group was not statictically significant. These data indicate that HYG protects on the CA 1 neurons, and this suggest that the suppression of adrenoceptors by this drugs may be the main mechnism of action. This morphologic outcome may explain the functional amelioration of mental impairment by HYG.