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Selective concentration of anti‐Purkinje cell antibody in the CSF of two patients with paraneoplastic cerebellar degeneration
Author(s) -
Graus F.,
Segurado O. G.,
Tolosa E.
Publication year - 1988
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1988.tb03648.x
Subject(s) - paraneoplastic cerebellar degeneration , pathology , antibody , pathogenesis , degeneration (medical) , medicine , cerebellum , cerebellar degeneration , immunology , autoantibody
‐ An anti‐Purkinje cell antibody (APCA) was found in serum and CSF of 2 patients with paraneoplastic cerebellar degeneration (PDC) and breast carcinoma. Integrity of the blood‐brain barrier (BBB) was normal in one patient and slightly damaged in the other. In both patients CSF IgG index was normal, but CSF/serum APCA ratio and CSF IgG APCA index were elevated suggesting that a selective concentration of the APCA in CSF occurs in patients with PCD. This feature supports the hypothesis that APCA may play a role in the pathogenesis of PCD.