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Hemiballismus: changes in cerebrospinal fluid
Author(s) -
Kostic V.,
Djuricic B.,
Paschen W.
Publication year - 1988
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1988.tb03631.x
Subject(s) - homovanillic acid , cerebrospinal fluid , dopamine , metabolite , phenylacetic acid , serotonin , medicine , chemistry , endocrinology , biochemistry , receptor
‐ Concentrations of serotonine metabilite, 5–hydroxyindoleacetic acid (5–HIAA), and dopamine metabolites, homovanillic acid (HVA) and 3,4‐dihydroxy‐phenylacetic acid (DOPAC), were measured in the samples of cerebrospinal fluid of 5 patients with acute hemiballismus. The only significant change was the increased content of HVA compared to controls. This finding support the hypothesis on the increased dopamine turnover in hemiballismus and provide a rational basis for the present treatment with antidopaminergic agents.