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Neuronal antinuclear antibody (anti‐Hu) in paraneoplastic encephalomyelitis simulating acute polyneuritis
Author(s) -
Graus F.,
Elkon K. B.,
Lloberes P.,
Ribalta T.,
Torres A.,
Ussetti P.,
Vails J.,
Obach J.,
AgustiVidal A.
Publication year - 1987
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1987.tb07928.x
Subject(s) - medicine , lung cancer , encephalomyelitis , pathology , anti nuclear antibody , antibody , cancer , immunology , peripheral nervous system , lung , central nervous system , multiple sclerosis , autoantibody
— A patient with paraneoplastic encephalomyelitis (PEM) and small cell lung cancer had a clinical presentation of acute polyneuritis. The patient had an antibody (anti‐Hu) resticted to nuclei of neurons identical to that reported in patients with subacute sensory neuronopathy and lung cancer. This finding further supports the hypothesis that PEM and subacute sensory neuronopathy are closely related disorders of autoimmune origin. PEM should be considered in patients with small cell lung cancer and clinical features limited to the peripheral nervous system.