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Positron emission tomography (PET) in the study of dopamine receptors in the primate brain: evaluation of a kinetic model using 11 C‐N‐methyl‐spiperone
Author(s) -
Eckernäs SÅ,
Aquilonius S M,
Hartvig P.,
Hägglund J.,
Lundqvist H.,
Någren K.,
Långstrom B.
Publication year - 1987
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1987.tb07913.x
Subject(s) - spiperone , positron emission tomography , receptor , kinetics , chemistry , nuclear medicine , iodine 123 , dopamine receptor , reaction rate constant , dopamine , physics , biophysics , neuroscience , medicine , biochemistry , biology , quantum mechanics
— The regional kinetics of 11 C‐N‐methyl‐spiperone ( 11 C‐NMSP) are described in the monkey brain under tracer conditions and after displacement and protection experiments. The primary aim of the study was to investigate different methodological problems associated with use of 11 C‐NMSP in the quantitation of receptor properties before applying the method in clinical research. Special emphasis was placed on the evaluation of different mathematical approximations of a general compartment model. Different mathematical procedures are described and the results indicate that the approximations performed are reasonable. The simplest method for obtaining a reliable measurement of the rate constant k 3 (which is ∼ proportional to the number of receptors) and k 4 (the receptor dissociation rate constant) uses the radioactivity in the cerebellum as a measure of the tissue concentration of ligand equilibrating with the receptor compartment.