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Acute multiple sclerosis exacerbations are characterized by low cerebrospinal fluid suppressor/cytotoxic T‐cells
Author(s) -
Antonen J.,
Syrjälä P.,
Oikarinen R.,
Frey H.,
Krohn K.
Publication year - 1987
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1987.tb07911.x
Subject(s) - exacerbation , multiple sclerosis , cytotoxic t cell , cerebrospinal fluid , immunology , medicine , inducer , t lymphocyte , immune system , biology , in vitro , biochemistry , gene
— The present study describes peripheral blood (PB) and CSF T‐lym‐phocyte subpopulations in 55 MS patients with and without acute exacerbation and compares the results with those obtained from 8 with CNS infections and 45 with other neurological disorders or symptoms (OND). The MS patients were most strongly characterized by a decline of their CSF suppressor/cytotoxic T‐cells, which was most profound during acute exacerbations. The proportional amount of CSF helper/inducer T‐cells (T h ) was higher in both MS group than in the OND group, but not different from that of the CNS infection group. No statistically significant change in the CSF T h ‐cells during exacerbations was seen. MS patients without an exacerbation had somewhat higher levels of their PB T h ‐cells than the patients with OND, but otherwise no differences in the PB T‐cell subsets were seen.