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Abnormal relaxation rates in subjects susceptible to malignant hyperthermia
Author(s) -
Lennmarken C.,
Rutberg H.,
Henriksson K. G.
Publication year - 1987
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1987.tb07898.x
Subject(s) - malignant hyperthermia , skeletal muscle , adductor pollicis muscle , muscle relaxation , ulnar nerve , medicine , hyperthermia , calcium , muscle contraction , contraction (grammar) , relaxation (psychology) , anesthesia , endocrinology , anatomy , elbow
— The acute malignant hyperthermia crisis appears to be mediated by asudden and sustained rise in the concentration of sarcoplasmic calcium, leading to a prolonged muscle contraction. It is not known whethr clcium metabolism in skeletal muscie is abnormal in malignant hyperthermia susceptible (MHS) subjects under normal condition. Ahpermetabolic state in skeletal muscle can be assessed in vivo by measuring relaxation rate. In the present study the relaxation rate was measured in the adductor policis muscle after electerical stimulation of the ulnar nerve. Ten MHS subjects with no clinical symptoms of muscle disease were investigated. Relaxation rates were found to be significantly higher in the MH‐susceptible subects compared with controls even under normal condition ( p 0.0001). Determination of relaxtion rate could thus be considered a possible addition to those methods currently available for the diagnosis of MHS.