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Bannwarth's syndrome: serum and CSF IgG antibodies against Borrelia burgdorferi examined by ELISA
Author(s) -
Hofstad H.,
Matre R.,
Nyland H.,
Ulvestad E.
Publication year - 1987
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1987.tb07886.x
Subject(s) - borrelia burgdorferi , antibody , borrelia , immunology , medicine , lyme disease , neurosyphilis , syphilis , human immunodeficiency virus (hiv)
— A newly identified spirochete, Borrelia burgdorferi , has recently been established as the causal agent of chronic meningoradiculitis (Bannwarth's syndrome, BS). An etiological diagnosis can be obtained by specific antibody determination. To detect intrathecally produced Borrelia antibodies, we examined paired serum and CSF samples from 10 BS patients and 41 controls. CSF/serum IgG specific antibody indices were calculated by relating the CSF/serum ratio of specific antibody activity to the CSF/serum ratio of total IgG and of albumin; 8/10 BS patients compared to 4/39 controls had elevated index values. In only one of the 4 positive controls could spirochetal infection be excluded. We conclude that determination of specific antibody indices is a reliable and sensitive diagnostic test for nervous system B. burgdorferi infection.