Premium
Somatostatin suppression of meningioma cell proliferation in vitro
Author(s) -
KunertRadek J.,
Stepien H.,
Radek A.,
Pawlikowski M.
Publication year - 1987
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1987.tb05474.x
Subject(s) - meningioma , somatostatin , somatostatin receptor , in vitro , cell growth , thymidine , somatostatin receptor 2 , cell culture , proliferation index , cancer research , medicine , biology , endocrinology , cell , pathology , chemistry , microbiology and biotechnology , biochemistry , genetics
Considering the presence of a stereospecific receptor for somatostatin (SST) in human meningioma cells and the possible involvement of this neuropeptide in the growth control of certain meningioma cell lines, the effects of SST on the proliferation of human meningioma cells in virto was investigated. Tumour tissues for primary cell cultures were obtained surgically from 2 women with histopathological diagnosis of meningothelial meningioma. The incorporation of [ 3 H]‐thymidine into meningioma cells DNA was measured as an index of the cells proliferation. It was shown that SST (10 ‐7 ‐10 ‐5 M) significantly inhibited the [ 3 H]‐thymidine incorporation. The results have indicated that SST may have an antiproliferative effects on the meningioma tumour cells in virto.