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Muscle antibodies in the cerebrospinal fluid from patients with myasthenia gravis
Author(s) -
Thorlacius S.,
Aarli J.A.,
Gilhus N.E.,
Hofstad H.
Publication year - 1987
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1987.tb05472.x
Subject(s) - myasthenia gravis , cerebrospinal fluid , antibody , acetylcholine receptor , medicine , agarose , immunoglobulin g , chemistry , agarose gel electrophoresis , immunology , endocrinology , receptor , chromatography , biochemistry , gene
ABSTRACT IgG antibodies to nicotinic acetylcholine receptor (AChR) and to a muscle antigen extracted by citric acid, were quantified in serum and cerebrospinal fluid (CSF) from 28 patients with myasthenia gravis, and the serum:CSF ratios compared with those of total IgG. Agarose‐electrophoresis and calculations of the IgG index and Tourtellotte's formula were performed. No evidence of intrathecal antibody synthesis was demonstrated. Compared to the total IgG concentrations in serum and CSF, the CSF concentrations of IgG AChR antibodies were lower than expected.