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Experimental meningitis in the rabbit. I. Arterial blood pressure and acid‐base balance during halothane anesthesia and in situ freezing of the brain
Author(s) -
Lindquist L.,
Bentin R.,
Hedström K.G.,
Lundbergh P.
Publication year - 1987
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1987.tb05468.x
Subject(s) - hypocapnia , halothane , anesthesia , medicine , anesthetic , acidosis , blood pressure , pco2 , acid–base homeostasis , hyperventilation , arterial blood , metabolic acidosis , hypercapnia
Effects of halothane/N 2 O anesthesia and in situ freezing of the brain on mean arterial blood pressure (MABP), pH, pCO 2 and pO 2 were evaluated in rabbits with either Srreprococcus pneumoniae or Escherichia coli meningitis. Prior to anesthesia infected rabbits had, compared to controls, significantly lower values for MABP and pCO 2 , either with a compensated ( S. pneumoniae group) or decompensated ( E.coli group) metabolic acidosis. In most animals a slight additional decrease in MABP was observed during anesthesia. With maintained pre‐anesthetic hypocapnia no further disturbance in acid‐base balance occurred during anesthesia. After one minute of freezing MABP increased towards preanesthetic levels. We conclude that the technique for in situ freezing of the brain under halothane/N 2 O anesthesia may be applied for studies of cerebral metabolism in rabbit with experimental meningitis.