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Inhibition of glial proliferation in vitro by serum from patients with multiple sclerosis
Author(s) -
Ferraro D.,
Salemi G.,
Cestelli A.,
Chiarini A.,
Savettieri G.
Publication year - 1987
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1987.tb03573.x
Subject(s) - multiple sclerosis , in vitro , inhibitory postsynaptic potential , thymidine , cell growth , medicine , immunology , cell culture , neuroglia , cell , stage (stratigraphy) , fetal bovine serum , biology , pathology , endocrinology , central nervous system , biochemistry , paleontology , genetics
Primary cell cultures from fetal rat CNS have been employed to evaluate the effects caused by the addition of serum from patients affected by multiple sclerosis (MS). MS‐serum supplemented media caused a decrease in [3H]‐thymidine incorporation into the cultures, thus indicating an inhibitory effect on proliferating glial cells. Sera from patients in remission stage of the disease showed an inhibitory effect not significatively lower than those from patients in acute stage. These results suggest that glial cells may be a target of circulating factors present in MS.