Premium
Clinical and muscle biopsy findings in malignant hyperthermia susceptibility
Author(s) -
Ranklev E.,
Henriksson KG,
Fletcher R.,
Germundsson K.,
Oldfors A.,
Kalimo H.
Publication year - 1986
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1986.tb07870.x
Subject(s) - malignant hyperthermia , central core disease , muscle biopsy , medicine , biopsy , pathology , electromyography , vastus medialis , physical medicine and rehabilitation , ryanodine receptor , calcium , ryr1
— Patients (155) were investigated for malignant hyperthermia susceptibility (MHS), by in vitro testing of muscle taken from the vastus medialis muscle. Histopathological and histochemical investigation of muscle was also performed. Ultrastructural investigation was performed in 13 MHS patients; 90% of the patients replied to a questionnaire concerning present or previous neuromuscular symptoms. The majority of MHS and MH negative (MHN) patients had no or only minor histopathological and histochemical abnormalities. Core‐targetoid fibres were the only potentially important abnormalities found in MHS patients. There were no differences in neuromuscular symptoms between MHS, MHN and control patients, and most patients in both the MHS and MHN group were normal on clinical examination.