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Measurement of beta‐2‐microglobulin in human cerebrospinal fluid by ELISA technique
Author(s) -
Bjerrum O. W.,
Lage S.,
Hansen O. E.
Publication year - 1986
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1986.tb07851.x
Subject(s) - beta 2 microglobulin , cerebrospinal fluid , beta (programming language) , beta globulins , medicine , central nervous system , body fluid , pathology , chemistry , immunology , antibody , gamma globulin , computer science , programming language
— This study introduces an enzyme‐linked immunosorbent assay for measurement of beta‐2‐microglobulin in human cerebrospinal fluid. The concentration of beta‐2‐microglobulin in cerebrospinal fluid correlated with the age ( p < 0.001) of a control group of 40 subjects, probably reflecting age‐related processes in the central nervous system. The reference interval of beta‐2‐microglobulin was considered to be 0.62‐3.28 mg/1. Results obtained with various CNS disorders demonstrated that estimation of beta‐2‐microglobulin in cerebrospinal fluid add diagnostic information. The concentration of beta‐2‐microglobulin may increase without simultaneous aberrations in the content of protein, glucose and white blood cells.