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Carbamazepine lowering effect on CSF somatostatin‐like immunoreactivity in temporal lobe epileptics
Author(s) -
Steardo L.,
Barone P.,
Hunnicutt E.
Publication year - 1986
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1986.tb04640.x
Subject(s) - carbamazepine , somatostatin , temporal lobe , epilepsy , medicine , anticonvulsant , pharmacology , anesthesia , neuroscience , psychology , psychiatry
The effect of carbamazepine treatment on CSF‐somatostatin‐like immunoreactivity (SLI) in patients suffering from temporal lobe epilepsy was investigated. A baseline lumbar puncture was performed on 12 patients and 10 normal volunteers. A second tap was repeated only in patients when they were on peak of carbamazepine concentration for 10 days. Levels of CSF‐SLI were measured by RIA. No significant differrences were found in CSF‐SLI basal concentrations between epileptics and controls, whereas a significant decrease ( p < .0002 Duncan's multiple range test) of CSF peptide levels occurred in 9 of 12 patients under medication. Although the neural mechanism through which carbamazepine lowers CSF‐SLI is still unknown, the results of the present study suggest that the reported effect might be part of the apparatus by which carbamazepine exerts its anticonvulsant action.