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Withdrawal of phenobarbital and carbamazepine in epileptic patients: a preliminary neuropsychological report.
Author(s) -
Gallassi R.,
Lorusso S.,
Stracciari A.,
Morreale A.,
Procaccianti G.,
Baruzzi A.
Publication year - 1986
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1986.tb04626.x
Subject(s) - carbamazepine , phenobarbital , neuropsychology , anesthesia , medicine , anticonvulsant , epilepsy , vigilance (psychology) , neuropsychological test , psychology , psychiatry , cognition , pharmacology , neuroscience
We systematically investigated the neuropsychological effects of controlled withdrawal of antiepileptic therapy with a battery of tests exploring intelligence, vigilance, attention, memory and sensori‐motor performance. 16 patients without seizures for at least 2 years, 9 on therapy with phenobarbital (PB) and 7 with carbamazepine (CBZ), were examined 4 times over a period of 21 months. No significant correlation was found between drug levels and performance in the tests. The slight differences found between the PB and CBZ groups at full doses disappeared completely one year after withdrawal.