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LDH isoenzymes in CSF in the diagnosis of neonatal brain damage
Author(s) -
Fernández F.,
Quero J.,
Verdú A,
Ferreiros M.C.,
Daimiel E.,
Roche M.C.
Publication year - 1986
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1986.tb04621.x
Subject(s) - cerebrospinal fluid , medicine , lactate dehydrogenase , encephalopathy , brain damage , isozyme , hypoxic ischemic encephalopathy , anesthesia , pediatrics , pathology , biology , biochemistry , enzyme
Lactate dehydrogenase isoenzymes in cerebrospinal fluid were measured during the first 24 h of life in 25 asphyctic neonates. The infants were subjected to clinical and developmental examinations for a mean follow‐up period of 15.2 months. The mean values for cerebrospinal LDH 2 (MH 3 ) and LDH 3 (M 2 H 2 ) isoenzymes were significantly higher in asphyctic infants who died from hypoxic‐ischemic encephalopathy or who survived but suffered neurologic sequelae, than they were in those asphyctic infants who survived and were normal in the follow‐up studies. Therefore, the authors conclude that the lactate dehydrogenase isoenzyme pattern in cerebrospinal fluid may be of value when assessing anoxic brain damage.