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Benign monoclonal IgA K gammopathy associated with polyneuropathy and dysautonomia
Author(s) -
Bailey R.O.,
Ritaccio A.L.,
Bishop M.B.,
Wu AnYa
Publication year - 1986
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1986.tb04602.x
Subject(s) - polyneuropathy , medicine , dysautonomia , peripheral neuropathy , pathology , monoclonal gammopathy of undetermined significance , gammopathy , myelin , monoclonal , immunology , monoclonal antibody , antibody , disease , endocrinology , central nervous system , diabetes mellitus
The first case of benign IgA K monoclonal gammopathy associated with peripheral neuropathy is described. Dysautonomia is an unusual, yet prominent, manifestation of neuropathy in this patient. Electrodiagnostic testing and nerve biopsy were compatible with demyelination and axonal loss. Myelin sheath, perineural, and endoneural interstitial tissue fixation of anti‐IgA and anti‐kappa light chains was demonstrated by direct immunofluoresence microscopy. Absorption studies utilizing human peripheral nerve myelin resulted in complete removal of the paraprotein band. Analytic procedures with myelin‐associated glycoprotein and gangliosides, however, were negative. Based on these findings, an alternative etiology for this neuropathy is hypothesized.