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A comparison between regional cerebral blood flow measurements obtained in human subjects using 11 C‐methylalbumin microspheres, the C 15 O 2 steady‐state method, and positron emission tomography
Author(s) -
Brooks D. J.,
Frackowiak R. S. J.,
Lammertsma A. A.,
Herold S.,
Leenders K. L.,
Selwyn A. P.,
Turton D. R.,
Brady F.,
Jones T.
Publication year - 1986
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1986.tb03298.x
Subject(s) - microsphere , cerebral blood flow , ventricle , grey matter , nuclear medicine , blood flow , white matter , positron emission tomography , steady state (chemistry) , hemodynamics , medicine , chemistry , nuclear magnetic resonance , anesthesia , magnetic resonance imaging , cardiology , physics , radiology , chemical engineering , engineering
Regional cerebral blood flow (rCBF) values were measured in nine normotensive subjects with known previous myocardial infarctions using 15μ 11 C‐methylalbumin microspheres and positron emission tomography (PET). Microspheres were injected directly into the left ventricle of each subject during routine cardiac angiography and blood flow calibrated using the reference sample technique. rCBF values were compared with those obtained for a group of fifteen age‐matched normal controls using the C 15 O 2 steady‐state inhalation technique. Using 1 cm radius circular regions of interest, the 11 C‐microspheres approach yielded mean blood flow values of 51 ml/100 ml/min and 48 ml/100 ml/min for regions of interest dominated by temporal and frontal cortical grey matter respectively. An rCBF value of 32 ml/100 ml/min was obtained for regions of interest dominated by frontal white matter. Mean rCBF values obtained for these regions using the C 15 O 2 method were not significantly different (52 ml/100 ml/min, 44 ml/100 ml/min, and 28 ml/100 ml/min respectively), but the C 15 O 2 approach gave a significantly lower rCBF value than the 11 C‐microspheresfor regions of interest dominated by occipital grey matter. Although the two groups of subjects studied were not strictly equivalent, the good agreement between blood flow values obtained using the 11 C‐microspheres and the C 15 O 2 techniques is of interest, and suggests that the assumptions of the C 15 O 2 steady‐state approach do not lead to large errors in practice.