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Clozapine in the treatment of tremor
Author(s) -
Pakkenberg H.,
Pakkenberg B.
Publication year - 1986
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1986.tb03279.x
Subject(s) - essential tremor , clozapine , medicine , sedation , anesthesia , movement disorders , schizophrenia (object oriented programming) , physical medicine and rehabilitation , psychiatry , disease
In an open trial 25 tremor patients were treated with clozapine in small doses (18–75 mg per day). The effect was measured with a new movement analyzer. Nine of 12 essential tremor patients were greatly improved. In six of nine patients with Parkinson tremor and in two combined essential tremor/Parkinson tremor patients tremor almost disappeared. Sedation is a major side effect, but decreases in most patients with time. The risk of agranulocytosis makes blood control necessary.