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Cerebrospinal fluid levels of myelin basic protein and creatin kinase BB as index of active demyelination
Author(s) -
MatiasGuiu J.,
MartinezVazquez J. M.,
Ruibal A.,
Codina A.
Publication year - 1986
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1986.tb03264.x
Subject(s) - myelin basic protein , radioimmunoassay , cerebrospinal fluid , medicine , multiple sclerosis , exacerbation , myelin , immunology , pathology , central nervous system
Radioimmunoassay‐determined myelin basic protein (MBP) shed to CSF during active demyelination, has been found to be a useful but non‐specific test for MS. CSF creatin kinase BB (CK‐BB), as measured by radioimmunoassay, is increased in a variety of neurological diseases, and has been considered a useful indication of brain damage but not of demyelinating diseases. Taking into account that the mean concentration of CSF CK‐BB should not be increased in patients during the acute phase of MS, we suggest that the CSF MBP/CK‐BB ratio could be a more specific index to demyelination than CSF‐MBP alone. We also defined a laboratory demyelination pattern (CSF MBP>mean control MBP + 2 S.D. and CK‐BB