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Encephalitogenic peptide and platelet aggregation in multiple sclerosis
Author(s) -
Prosiegel Mario,
Neu Ingo,
Mehlber Leonhard
Publication year - 1986
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1986.tb03255.x
Subject(s) - multiple sclerosis , platelet , pathogenesis , peptide , platelet aggregation , medicine , endocrinology , immunology , chemistry , biochemistry
Platelet aggregation (PA) stimulated by encephalitogenic peptide (EP) and PA induced by ADP were measured in 83 multiple sclerosis (MS) patients and 70 control subjects with other neurological diseases (OND). EP‐stimulated PA was significantly increased in MS patients as compared with the controls. There was no significant difference in ADP‐induced PA between patients with MS and OND. The results are discussed in terms of EP‐stimulated platelets playing a role in the pathogenesis of MS by affecting the venular permeability of the brain.