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Quantitative analysis of morphological features in Huntington's disease
Author(s) -
Roos R. A. C.,
Bots G. Th. A. M.,
Hermans J.
Publication year - 1986
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1986.tb03253.x
Subject(s) - huntington's disease , nucleus accumbens , linear discriminant analysis , caudate nucleus , psychology , disease , discriminant , pathology , neuroscience , medicine , central nervous system , artificial intelligence , computer science
In an electron microscopic study neuronal nuclear membrane indentations and astrocyte/neuron ratios in the nucleus accumbens, caudate nucleus and frontal cortex were counted in 30 Huntington's disease patients and 23 controls. Discriminant analysis was performed and resulted in a discriminant equation, which was able to recognize all controls correctly. Three Huntington patients were not correctly recognized, although in only one patient the probability of being a control was higher than being a Huntington patient. This discriminant equation was used in four choreatic patients with a negative family history. Two patients were indicated as controls, one patient as being a Huntington patient, and one as dubious. The diagnostic yield of discriminant analysis is discussed.