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Different metabolism of vitamin D 2 and vitamin D 3 in epileptic patients on carbamazepine
Author(s) -
Tjellesen L.,
Christiansen C.,
Rodbro P.,
Hummer L.
Publication year - 1985
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1985.tb03217.x
Subject(s) - carbamazepine , vitamin , vitamin d and neurology , serum concentration , endocrinology , medicine , metabolism , anticonvulsant , epilepsy , chemistry , psychiatry
– Serum concentrations of vitamin D metabolites were measured in 30 epileptic outpatients on monotherapy with carbamazepine before and during treatment with either vitamin D 2 or vitamin D 3 , 4000IU per day for 24 weeks. Vitamin D 2 treatment increased the serum concentration of 25OHD 2 , but a corresponding decrease in 25OHD 3 resulted in an unchanged serum value of total 25OHD. Vitamin D 3 treatment increased the serum concentration of 25OHD 3 . The resulting serum level of 25OHD was consequently twice the level of that in the D 2 ‐treated group. The serum concentrations of the dihydroxy metabolites showed a similar difference between the 2 treatment groups. We conclude that treatment with vitamins D 2 and D 3 in the same doses produces considerably different serum concentrations of vitamin D metabolites. If the present findings can be extrapolated to normal subjects, it is important to consider more carefully which D‐vitamin should be used, both with regard to therapy and supplementation.