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Early diagnosis of herpes simplex virus encephalitis in childhood by the enzyme‐linked immunosorbent assay
Author(s) -
Sugimoto Tateo,
Sakane Yoshimi,
Kobayashi Yohnosuke
Publication year - 1985
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1985.tb03213.x
Subject(s) - herpes simplex virus , encephalitis , antibody , medicine , virology , simplexvirus , immunology , immunoglobulin g , virus , herpesviridae , viral disease
– IgG antibody of cerebro‐spinal fluid (CSF) and serum IgM antibody were determined by the enzyme‐linked immunosorbent assay (ELISA) in 3 patients with herpes simplex virus encephalitis (HSVE). The ELISA detected the early rise of IgG antibody for herpes simplex virus (HSV) in CSF on the 3rd/4th day from onset of symptoms and IgM antibody in serum similarly on the 3rd/4th day, respectively. CSF albumin, IgG index and daily IgG synthesis during the early phase of HSVE showed significantly high levels. However, there was no significant increase of complement‐fixing antibody and neutralizing antibody for HSV of serum and CSF in 2 of 3 patients. The ELISA turned out to be a more sensitive and convenient test for the early diagnosis of HSVE.